CERO 3D Incubator & Bioreactor

Revolutionize Your 3D Cell Culture

Making the Impossible Possible

The CERO 3D Incubator & Bioreactor offers a unique 3D cell culture technology to boost your organoid, spheroid, stem cell, and tissue research. This revolutionary instrument creates an optimal cell culture environment by monitoring and controlling temperature, pH and CO₂ levels.

Advanced 3D Culturing
Embrace the full potential of three-dimensional cell growth for tissue engineering, cancer research, and more.
High-throughput Capability
Efficiently manage multiple experiments simultaneously, saving time and resources.
Precise Control
Fine-tune your environmental parameters with unparalleled accuracy for consistent results.
User-friendly Interface
Our intuitive design ensures a seamless integration into your lab routine.

[glossary]Saving time, enhancing quality, and paving new paths.[/glossary]

Prof. Dr. L. Sevenich and A. Wolfram

Meet CERO 3D

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Spheroid Formation of Edited iPSCs

CERO Key Features

Beating of mature cardiac organoids in the CERO 3D.

Innovative Design
Our patented bioreactor chambers are designed to facilitate the natural growth patterns of cells, allowing for nutrient flow and waste removal just as they would occur within a living organism.
Versatility at Its Core
Whether you’re conducting research in oncology, stem cells, or toxicology, CERO adapts to your needs. Its compatibility with numerous cell types and matrices makes it a universal tool for every laboratory.
Seamless Integration
CERO’s compact footprint and plug-and-play setup ensure that incorporating it into your lab is as straightforward as its operation.

Trusted by Hundreds of Labs Worldwide

[glossary]Scalable stem cell processes with minimal starting volumes.[/glossary]

Dr. J. Neubauer

Managing Director at Fraunhofer Project Center for Stem Cell Process Technology

[glossary]CERO 3D advances liver tissue research like never before.[/glossary]

Prof. Dr. A. Nüssler and Prof. Dr. S. Ehnert

Generation of HepaRG Spheroids in the CERO

A 3D model for investigation of Hepatitis B Virus infections

Establishment and validation of the 3D cultivation system “CERO” for hepatic spheroids to study viral hepatitis

Standardized generation of human iPSC‑derived hematopoietic organoids and macrophages

3D Cell Culture CEROplates

96-well, U-bottom shaped, ready-to-use plates
Support uniform spheroid and organoid formation
Allow long-term 3D culture over months
Anti-adhesive surface inhibits cellular attachment
Compatible with existing imagers, liquid handling, and automated stations
Improves data consistency
Suitable for high-throughput applications

The ultra-low attachment CEROplate simplifies the process for growing 3D aggregates. It features clear wells with a U-bottom to make sample monitoring simple. The unique well geometry of the microplate aids in the formation of an unattached, round-shaped, single spheroid or organoid in the center of each well.

This allows you to assay and analyze your 3D aggregates in the same plate without transfer. The CEROplates are compatible with existing readers, imaging systems, liquid handling, and automated workstations.

The CellRaft AIR® Is the Perfect Complement to the CERO 3D

Transform Your Organoid Workflow: The CellRaft AIR® + CERO 3D

Maintain a complete record of organoid growth over multiple time points
Perform on-array phenotypic assessment
Fully automate isolation of individual viable, intact organoids of interest
Generate customized 96-well plates for organoid-based assays such as clonal propagation, drug or toxicity screening, or target discovery