Circulating Tumor Cells & Metastasis
Advance Oncology Research
BioFlux Shear Flow Systems revolutionize cancer research by replicating blood vessel conditions to study circulating tumor cells (CTCs) and metastasis mechanisms. This innovative platform combines the precision of in vitro control with physiologically relevant conditions, delivering insights impossible with traditional methods.
The high-throughput platform enables up to 24 independent experiments per plate, accelerating your research and drug discovery pipeline. This efficient design allows rapid evaluation of multiple cell types, treatment combinations, and experimental conditions.
BioFlux CTC & Metastasis Applications
- Track cancer cell behavior in real-time through critical metastatic stages – from initial adhesion to transmigration and invasion
- Quantify cell adhesion strength under varying shear stress conditions to predict metastatic potential
- Evaluate treatment efficacy using physiologically relevant models with primary endothelial cells or protein matrices
- Screen and identify aggressive tumor phenotypes to develop targeted therapeutic strategies
Key Advantages of BioFlux CTC & Metastasis Assays
- Use time-lapse imaging to capture the process of adhesion and transmigration, or run as endpoint for high throughput discovery
- Analyze the different steps of cancer progression and epithelial-mesenchymal transition with cancer cells under shear flow
- Flow allows for easy washing of unbound cancer cells
- Microfluidic design allows for each experiment to utilize as little as 100 µl of patient blood
Circulating Tumor Cells
A representative video showing rolling behavior in MDA cells through E-selectin-coated microfluidic channels. doi.org/10.1371/journal.pone.0085143
Metastasis
A condensed video of FT7 deficient prostate cancer cells cell breaching of vascular endothelium. doi.org/10.1158/0008-5472.CAN-12-3264