Physiological flow has a profound impact on many biological processes, such as thrombus formation, cell adhesion, and endothelial cell permeability.
BioFlux Shear Flow Systemsgive you the ability to mimic physiological flow in your research and drug discovery experiments to reveal the true biology.
Check the application pages to see how BioFlux can accelerate your live cell assays.
“Given the critical role of shear in regulating platelet adhesion and thrombus growth, these findings may have potential pathophysiological significance.” [Jackson, et al., 2006]
Cell Biology Applications
Atherosclerosis
Examine atherosclerosis using primary plaques or cell co-culture models
BioFlux was used in a recent study modeling catheter-associated infection by using BioFlux microfluidics to mimick the in vivo conditions of urinary catheters. In their lab, the BioFlux 200 system has been used to evaluate the efficacy of poloxamers in reducing E. coli adhesion under controllable shear forces by exploiting BioFlux silicone microfluidic flow channels, thus mimicking the in vivo conditions of urinary catheters in terms of both flow conditions and catheter material.