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Tumor Microenvironment

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To comprehend the intricacies of cancer cells in full, analyzing the tumor microenvironment in vitro is crucial. BioFlux Shear Flow Systems are high-throughput platforms ideal for analyzing several oncological processes, including the impact of a tumor microenvironment. By controlling shear stress, temperature, attachment substrate, and gas composition, BioFlux creates a physiologically relevant atmosphere for oncological assays.

Create and Control Tumor Microenvironments with BioFlux

  • Tightly controlled shear stress from 0-200 dyn/cm² mimic different tissue environments 
  • Assay under hypoxic or differential gas composition conditions
  • Easily control temperature while imaging 
Cell-Cell Interactions
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MCF-7 cells (alone and LPS-treated THP-1) adherent to HUVEC layers under shear flow (Khismatullin et al., 2014).
Treatment Effects
Cancer cell apoptosis
The effects of PTF on apoptosis induction in NCI-H1703 cells. (Zhao et al., 2015)
Cell Conditioning
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CHO cells were conditioned and examined under shear flow. Cells were then released from the BioFlux plate and examined using flow cytometry (Le Pendu et al., 2016).

Key BioFlux Advantages For Tumor Microenvironment Studies

  • Determine IC50 concentrations or screen up to 24 compounds per plate
  • Manipulate microenvironment by flowing anti-inflammatory compounds or anti-cancer treatments into channels
  • Closely examine the connections between tumor and surrounding cells or molecules on a microfluidic platform
  • Easy real-time or endpoint imaging
Learn more about BioFlux