Adhesion and aggregation reaction of platelets are critical processes in hemostasis, preventing excessive bleeding following vascular injury. Generally, circulating platelets have a lifespan of about 10-12 days, after which they undergo programmed cell death or necrosis and are taken up by macrophages. Importantly, abnormal platelet adhesion to the vessel wall can lead to thrombosis, resulting in pathological clot formation and contributing to conditions such as heart attack or stroke. In this webinar, Dr. Mohammad Ekhlak of the Center for Advanced Research on Platelet Signaling and Thrombosis Biology at the Institute of Medical Sciences, Banaras Hindu University discusses high throughput evaluation of the effects of novel drugs on physiological thrombosis formation.
Dr. Ekhalk shares insights on:
1. In vitro modeling of physiological platelet plug formation
2. Antiplatelet/antithrombotic effects of novel pharmaceuticals
3. Signaling mechanisms of thrombosis
