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This study focuses on accumulation of somatic mutations in comparison to age. Mutations were compared between hepatocytes and liver stem cells. Single cells were seeded in a CellRaft Array and allowed to expand over several days before being isolated using the AIR System. Wells were expanded and reached a total amount of 1.5 to 3 million cells per parent clone after splitting. The entire process of establishing a clone from a single cell took about 25 to 30 days. Individual cells from the parent clone were re-seeded on a new CellRaft Array and allowed to settle. CellRaft containing a single cell were isolated into PCR tubes before being single-cell whole genome amplified and sequenced. Using the CellRaft Array this study was able to determine that a large number of mutations were found in functional parts of the liver genome, suggesting that somatic mutagenesis could contribute to age-related functional decline and increased incidence of disease of human liver.