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Publication: The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium

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Leukocyte (WBC) capture on both platelets and vascular endothelium plays a key role in the initiation of acute inflammation. In this publication, a BioFlux shear flow system was used to image the adhesion of leukocytes in whole blood and isolated neutrophils to HUVECs under shear stress conditions. These investigators were able to leverage a BioFlux to determine that neutrophil adhesion is reduced due to rhRod co-localization with P-selectin during endotoxemia.

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A journal article using BioFlux glass bottom plates

Simulation and Modeling of the Adhesion of Staphylococcus aureus onto Inert Surfaces under Fluid Shear Stress

A BioFlux Shear Flow System with glass bottom plates was used by Shaikh et al. to investigate the effects of shear stress on the adhesion...

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Chrysophanol-Functionalized Silver Nanoparticles for Anti-Adhesive and Anti-Biofouling Coatings to Prevent Urinary Catheter-Associated Infections

In this investigation by Prateeksha et al., a BioFlux Shear Flow System with custom substrate bottom plates was used to assess the effectiveness of silver...

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The Multifunctional Role of Poloxamer P338 as a Biofilm Disrupter and Antibiotic Enhancer: A Small Step forward against the Big Trouble of Catheter-Associated Escherichia coli Urinary Tract Infections

De Angelis et al. used a BioFlux Shear Flow System with silicone bottom plates to investigate the use of poloxamer 388 (P338) as an anti-biofilm...

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