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Publication: Acute hyperglycemia increases sepsis related glycocalyx degradation and endothelial cellular injury: A microfluidic study

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Human umbilical vein endothelial cell (HUVEC) monolayers were established in BioFlux microfluidic channels and activated with TNF. Endothelial glycocalyx (EG) integrity was indexed by shedding of the EG components as well as thickness. Endothelial cell (EC) injury/activation was indexed by soluble biomarkers. Intracellular reactive oxygen species (ROS) was by fluorescence. The investigators concluded that BioFlux may be a useful platform to study endothelial barrier function and stress conditions and allow preclinical assessment of potential therapies.

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A journal article using BioFlux glass bottom plates

Simulation and Modeling of the Adhesion of Staphylococcus aureus onto Inert Surfaces under Fluid Shear Stress

A BioFlux Shear Flow System with glass bottom plates was used by Shaikh et al. to investigate the effects of shear stress on the adhesion...

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Chrysophanol-Functionalized Silver Nanoparticles for Anti-Adhesive and Anti-Biofouling Coatings to Prevent Urinary Catheter-Associated Infections

In this investigation by Prateeksha et al., a BioFlux Shear Flow System with custom substrate bottom plates was used to assess the effectiveness of silver...

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The Multifunctional Role of Poloxamer P338 as a Biofilm Disrupter and Antibiotic Enhancer: A Small Step forward against the Big Trouble of Catheter-Associated Escherichia coli Urinary Tract Infections

De Angelis et al. used a BioFlux Shear Flow System with silicone bottom plates to investigate the use of poloxamer 388 (P338) as an anti-biofilm...

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