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Junctional adhesion molecule-A (JAM-A, also known as F11R), a member of the immunoglobulin superfamily, is located in the tight junctions of epithelial and endothelial cells but also expressed by leukocytes and CD34+ cells, and exerts a wide variety of functions in cell polarity and barrier function via homophilic interactions, stem cell adhesion and differentiation, leukocyte trafficking, and recruitment. In this investigation, a BioFlux shear flow system was used to culture both human and mouse endothelial cells and treat them with LDL, oxidized LDL, and TNF-α. Using this data, the investigators were able to identify endothelial JAM-A as an effector to inflammatory cell entry at sites of atherosclerosis.