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Microbial cells growing as biofilms on medical device surfaces may show an enhanced antimicrobial tolerance with respect to their free-floating counterparts, due to physical or chemical barriers and increased transmission of resistance markers within biofilms. Investigators in this study used a BioFlux shear flow system to investigate P338 solution to detach biofilms under dynamic conditions. The group found that P338 destroyed Escherichia coli biofilms and contribute to biofilm detachment.